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Polycystic Ovary Syndrome (PCOS): Symptoms, Causes And Treatment

Polycystic ovary syndrome (PCOS) is a hormonal disorder that is very common in women of reproductive age nowdays. Women with PCOS may have fewer or longer periods or have excess male hormone (androgen) levels. The ovaries may develop multiple small collections of fluid (follicles) and fail to release eggs regularly.

The exact cause of PCOS is unknown. In early diagnosis and treatment along with weight loss can reduce the risk of long-term complications such as type 2 diabetes and heart disease. Polycystic ovary syndrome (PCOS) is a condition that affects a woman’s hormone levels. Women with PCOS produce more male hormones than normal. This hormone imbalance causes their body to skip menstruation and make it difficult for them to get pregnant. PCOS also causes hair growth and baldness on the face and body. And it can contribute to long-term health problems like diabetes and heart disease. Birth control pills and diabetes drugs (which combat insulin resistance, a PCOS symptom) can help to fix the hormone imbalance and improve symptoms.



What is PCOS?

PCOS is a hormonal problem that affects womens during their childbearing years (ages 15 to 44). Between 2.2 and 26.7 percent of women in this age group have PCOS. Many women have PCOS but don’t know it. In a study, up to 70 percent of women with PCOS hadn’t been diagnosed.

PCOS affects a woman’s ovaries, and reproductive organs that produce estrogen and progesterone — hormones that regulate the menstrual cycle. The ovaries also produce a small amount of male hormones called androgens.

The ovaries release eggs to be fertilized by a man’s sperm. The release of an egg each month is called ovulation. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are produced in the pituitary gland, control ovulation.

FSH stimulates the ovary to produce a follicle – a sac that contains an egg – and then LH triggers the ovary to release a mature egg.

PCOS is a “syndrome,” or group of symptoms that affects the ovaries and ovulation. Its three main features are:

  • Cysts in the ovaries
  • High levels of male hormones
  • Irregular or skipped periods
  • In PCOS, many small, fluid-filled sacs develop inside the ovaries. The word "polycystic" means "multiple cysts."

These sacs are actually follicles, each containing an immature egg. The eggs never mature enough to trigger ovulation.

The lack of ovulation alters levels of estrogen, progesterone, FSH, and LH. Progesterone levels are lower than usual, while androgen levels are higher than usual.

Extra male hormones disrupt the menstrual cycle, so women with PCOS get fewer periods than usual.



What causes it?

Doctors do not know exactly what causes PCOS. They believe that high levels of male hormones prevent the ovaries from producing hormones and producing eggs normally. Genes, insulin resistance and inflammation have all been linked to excess androgen production.

Genes

Studies show that PCOS runs in families.

It’s likely that many genes — not just one — contribute to the condition.

Insulin Resistance

Up to 70 percent of women with PCOS have insulin resistance, which means their cells cannot use insulin properly. Insulin is a hormone the pancreas produces to help the body use sugar from foods for energy.

When cells cannot use insulin properly, the demand for insulin in the body increases. The pancreas makes more insulin to compensate. Excess insulin triggers the ovaries to produce more male hormones.

Obesity is a major cause of insulin resistance. Both obesity and insulin resistance can increase your risk for type 2 diabetes.

Inflammation

Women with PCOS often have increased levels of inflammation in their body. Being overweight can also contribute to inflammation. Studies have linked excess inflammation to higher androgen levels.

Womens suffering with PCOS often have increased levels of inflammation in their bodies. Being overweight can also contribute to inflammation. Studies have linked excess inflammation to high androgen levels.

Common Symptoms Of  PCOS

Some women start seeing symptoms around the time of their first period. Others find out they have PCOS when they have gained a lot of weight or have had trouble getting pregnant.

The Most Common PCOS Symptoms Are:

Irregular Periods. The lack of ovulation every month prevents the uterine lining from shed. Some women with PCOS have fewer than eight periods a year or none at all. Heavy bleeding The lining of the uterus lasts longer, so your periods may be heavier than usual.

Hair Growth. More than 70 percent of women with this condition grow hair on their face and body – including hair on their back, abdomen and chest. Excessive hair growth is called hirsutism.

Acne. Male hormones can make the skin oilier than usual and cause breakouts on areas such as the face, chest and upper back.

Weight Gain. Up to 80 percent of women with PCOS are overweight or have obesity. Male pattern baldness. Hair on the scalp gets thinner and may fall out. Darkening of the skin. Dark patches of skin can form in body creases like those on the neck, in the groin, and under the breasts.

Headaches. Hormone changes can trigger headaches in some women.

How PCOS Affects Your Body?

Having higher-than-normal androgen levels can affect your fertility and other aspects of your health.

Infertility

To get pregnant, you have to ovulate. Women who do not ovulate regularly do not release as many eggs to be fertilized. PCOS is one of the major causes of infertility in women.

Metabolic Syndrome

Up to 80 percent of women with PCOS are overweight or have obesity (13Trusted Source). Both obesity and PCOS increase your risk for:

  • High blood sugar
  • High blood pressure
  • Low HDL “good” cholesterol
  • High LDL “bad” cholesterol

Together, these factors are called metabolic syndrome, and they increase the risk for:

  • Heart disease
  • Diabetes
  • Stroke

Sleep Apnea

This condition causes repeated pauses in breathing during the night, which interrupt sleep.Sleep apnea is more common in women who are overweight — especially if they also have PCOS. The risk for sleep apnea is 5 to 10 times higher in women who have both obesity and PCOS than in those without PCOS.

Sleep apnea is more common in women who are overweight – especially if they also have PCOS. The risk of sleep apnea is 5 to 10 times higher in women who have both obesity and PCOS, compared with women without PCOS.

Endometrial Cancer

During ovulation, the uterine lining sheds. If you don’t ovulate every month, the lining can build up.

A thickened uterine lining can increase your risk for endometrial cancer.

Depression

Both hormonal changes and symptoms like unwanted hair growth can negatively affect your emotions. Many with PCOS eventually experience depression and anxiety.



How PCOS Is Diagnosed?

Doctors typically diagnose PCOS in women who have at least two of these three symptoms:

  • High androgen levels
  • Irregular menstrual cycles
  • Cysts in the ovaries

Your doctor should also ask whether you’ve had symptoms like acne, face and body hair growth, and weight gain.

A pelvic exam can look for any problems with your ovaries or other parts of your reproductive tract. During this test, your doctor inserts gloved fingers into your vagina and checks for any growths in your ovaries or uterus.

Blood tests check for higher-than-normal levels of male hormones.

You may also have blood tests to check your cholesterol, insulin, and triglyceride levels to evaluate your risk for heart disease and related conditions such as diabetes.

Ultrasound uses sound waves to look for abnormal follicles and other problems with your ovaries and uterus.


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